top of page


Our Primary reserach interest revolves around the "Development of Green Organometallic Reagents and their applications to organic Synthesis. We embarked upon the development of Cross-couplings employing triarylbismuths as  3-fold coupling reagents in one-pot operation with sub-stoichiometric loadings. In this journey, we developed a new series of coupling reactions using triarylbismuth reagents with elaborate range of reactivity under palladium catalysis. These new couplings are blessed with higher atom-economy, faster reactivity and in general, with high yields.




Our research group also has interest in areas such as convergent organic synthesis, microwave-medaited synthesis, combined catalysis, organocatalysis, metal-carbenes and other areas of contemporary interest.


Research Interests


Prof. Maddali L. N. Rao


Department of Chemistry

IIT Kanpur

Kanpur - 208 016




New Generation Cross-coupling Reaction

Cross-couplings using Triarylbismuth reagents

Recent Publications


Rearrangement-Driven Molecular Diversity: Synthesis of Functionalized Pyrones, Orthoesters, and Xanthones from Spiroketals

Maddali LN Rao,* Sk Shamim Islam

Org. Lett. 2021, 23, 8668–8672

De Novo Synthesis of Tricyclic 5, 5-Benzannulated Spiroketals

Maddali LN Rao,* Sk Shamim Islam

Org. Lett. 2021, 23, 3944–3948


Copper-catalyzed domino synthesis of ynamines

Maddali LN Rao,* Sk Shamim Islam, Priyabrata Dasgupta

Org. Bio. Chem. 2021, DOI: 10.1039/d1ob01383


Pd‐Catalyzed Domino Cross‐Coupling: Synthesis of Functionalized 4‐(Arylethynyl) Coumarins

Maddali LN Rao,* Sachchida Nand, Venneti N Murty

Asian J. Org. Chem. 2021, 10, 1822-1827

Rapid Bis-coupling Reactivity with Triarylbismuth Reagents: Synthesis of Structurally Diverse Scaffolds and Step-economic Convergent Synthesis of Quebecol

Maddali L.N. Rao,* Venneti N. Murty, Sachchida Nand

Eur. J. Org. Chem. 2020, 1629-1636

Rh-Catalyzed aldehydic C-H alkynylation and annulation

Maddali L. N. Rao,* Boddu S. Ramakrishna

Org. Bio. Chem. 2020, 18, 1402-1411


Rh-Catalyzed Deformylative Coupling of Salicylaldehydes

with Acrylates and Acrylamides

Maddali L. N. Rao,* B. S. Ramakrishna

J. Org. Chem. 2019, 84, 5677-5683


Google Scholar.png
"Knowledge that liberates"

Triarylbismuths as Threefold Organometallic Reagents in Organic Synthesis

bottom of page